•Phase III RPCT of:
Se-methionine 200 ug/
and/or
vit E all-rac-alpha-tocopheryl
acetate 400 IU daily
4 groups including
placebo, intentionally for >7 yrs
•
•35,534 men >50/55 yrs (black/white)
•
•Stopped 2009 after an average of 5.5 yrs
•
•No reduction in prostate or other cancer risk.
•
•Se group non-statistically significant increase in
T2D
•
•Statistically significant increases in alopecia and dermatitis.
•
•Group will continue to be followed for several years