Statin
+ EPA Lipid Intervention Study, JELIS
Yokoyama M et al Lancet
2007;369:1090-98
•18,645 Japanese (69% F) with a total cholesterol >6.5
mmol/l
•Statin (pravastatin 10-20 mg or simvastatin 5 – 10
mg/day) or Statin + 3 x 600 mg
EPA ethyl ester /day; mean follow up 4.6 years
•Excluded many with serious diseases or haemorrhage
•EPA reduced major coronary events in those with a
history of CAD
Haemorrhage: cerebral, fundal, epistaxis, subcutaneous
Skin: eruption, itching, rash, eczema
GI
Disturbance: nausea, diarrhoea, epigastric discomfort
Pain: joint, lumbar muscle