•Acute toxicity: supplements mg doses:
muscle and
joint pains, hair loss, nail changes, sour taste, garlic breath and neurological
problems
•
•Chronic toxicity: diet or long term
supplement use
hair loss
dermatitis, bad breath, neurotoxicity
•
•Excess is excreted via faeces, integument and
breath
•
•Diagnosed by: raised plasma/whole blood or
hair Se.
•
•Possible association between Se. excess and
T2D but this may
reflect obesity or altered metabolism
Stranges S et al. 2010
•
•Safe supplement dose for long term use is probably <100
ug/day