•DBPC Trial 238
men and women (av. age 57 yrs)
•All had had Type 1 or 2 diabetes and mild diabetic
nephropathy
•Placebo or daily Folic acid 2.5 mg, vitamin B6 25 mg
and vitamin B12 1
mg for a mean of 31.9 months
•Assessment by radionuclide measure of Glomerular
Filtration Rate
•Measurement of plasma homocysteine
•Assessment of MI, stroke, need for vascular procedure
or all cause death =
composite end point
•Baseline: 89% male, BMI 32.0 kg/m2, very little
B12/folate deficiency