Clinical Picture of Chronic Retinol Excess
Reason or Clinical Picture
High from liver, fortified foods, supplements
?Increased in fast beta-carotene converters
Reduced in renal impairment
Reduced in elderly
Reduced storage in liver disease and alcohol XS.
Increased RBP4 if obese, T2D or ?Na valproate.
More susceptible to osteoporosis if vit D deficient
Increase in serum, liver and CSF levels
Headache, fatigue if hypercalcaemia
Raised CSF pressure, dry skin, hair loss, abnormal
liver function tests, bone changes – loss of height
Osteop. #, pregnancy deformity, ?cancer growth