Typically this vegetable-derived form of vitamin A is considered to be safe with a Safe Upper Level of 7,000 ug/day. However over 20 years ago the observation was made in experimental animals that supplements of beta-carotene might also aggravate alcohol-induced liver damage.
Again it is prudent not to exceed the Safe Upper Level of 7,000 ug per day and those with abnormal liver function tests or alcohol-induced liver disease should probably not take any supplements without expert advice.
The US expert position on beta-carotene is that it should only be used for the correction of proven vitamin A deficiency, which is known to be rare in adults.